Multiple new awards at KHRC!

Congrats to multiple investigators at the KHRC who have recently gotten Notice of Awards for new projects!

The following is a list of new awards in our group:

1. 1R01HL151564-01A1: Mitochondrial health, cardiovascular risk, and blood pressure targets in hypertensive adults

Multi-PI: Vasantha Jotwani, Michelle Odden, and Gregory Tranah (CPMC)

Project summary: Recent studies found that treating high blood pressure to a lower target reduces the risk of heart disease, stroke, and death, but the benefits and risks of lower blood pressure targets may differ from person to person. These projects will explore whether the health of mitochondria, the structures that convert energy into a form the body can use, affects the benefits or risks of lower blood pressure targets. The knowledge gained will help clinicians to personalize the treatment of high blood pressure, which could reduce the burden of heart disease among millions of individuals worldwide.

2. 1K76AG074903-01: Age-related changes in skeletal muscle and lower urinary tract symptoms in older adults

PI: Scott Bauer

Project Summary: The proposed research aims to understand new age-related mechanisms of lower urinary tract symptoms, which will lead to more accurate diagnosis and novel individualized treatments that improve or maintain health-related quality of life and physical function in older adults.

3. 1R01DK130870-01: Advanced Kidney Health Monitoring in Persons Hospitalized with Heart Failure

Multi-PI: Michelle Estrella and Jeffrey Testani (Yale)

Project Summary: Kidney complications occur commonly during heart failure treatment and strongly influence treatment decisions. However, current methods for monitoring kidney health are suboptimal. This proposal will develop a panel of kidney health biomarkers that could enable kidney-safe, effective treatment of heart failure.

4. 2R01AG034853-11: Biomarker-Based Diagnostic Algorithms To Prevent, Detect And Guide Treatment Of Kidney Disease In Persons Living With HIV

Multi-PI: Michael Shlipak and Michelle Estrella

Project Summary: Kidney disease is increasingly common in people living with HIV infection, but routine clinical tests are insensitive and cannot determine the specific causes. The findings from these projects will help clinicians to monitor kidney health and detect and treat earlier stages of kidney disease, which would allow unique opportunities for individualized prevention and treatment strategies in this high-risk population.